Hutley Louise, Prins Johannes B
Centre for Diabetes and Endocrine Research, University of Queensland, Australia.
Am J Med Sci. 2005 Dec;330(6):280-9. doi: 10.1097/00000441-200512000-00005.
Obesity and the metabolic syndrome have both reached pandemic proportions. Together they have the potential to impact on the incidence and severity of cardiovascular pathologies, with grave implications for worldwide health care systems. The metabolic syndrome is characterized by visceral obesity, insulin resistance, hypertension, chronic inflammation, and thrombotic disorders contributing to endothelial dysfunction and, subsequently, to accelerated atherosclerosis. Obesity is a key component in development of the metabolic syndrome and it is becoming increasingly clear that a central factor in this is the production by adipose cells of bioactive substances that directly influence insulin sensitivity and vascular injury. In this paper, we review advances in the understanding of biologically active molecules collectively referred to as "adipokines" and how dysregulated production of these factors in obese states mediates the pathogenesis of obesity associated metabolic syndrome.
肥胖和代谢综合征均已达到流行程度。它们共同有可能影响心血管疾病的发病率和严重程度，对全球医疗保健系统产生严重影响。代谢综合征的特征是内脏肥胖、胰岛素抵抗、高血压、慢性炎症和血栓形成紊乱，这些都会导致内皮功能障碍，进而加速动脉粥样硬化。肥胖是代谢综合征发展的关键因素，越来越清楚的是，其中一个核心因素是脂肪细胞产生直接影响胰岛素敏感性和血管损伤的生物活性物质。在本文中，我们综述了对统称为“脂肪因子”的生物活性分子的理解进展，以及肥胖状态下这些因子的产生失调如何介导肥胖相关代谢综合征的发病机制。
