Lin Weilong, Lin Ming-En
The First Affiliated Hospital of Shantou University Medical College, Medical College of Shantou University, Shantou, 515041, China.
Int Urol Nephrol. 2024 Mar;56(3):855-865. doi: 10.1007/s11255-023-03840-6. Epub 2023 Oct 16.
Currently, a growing number of research studies have shown a positive association between obesity and erectile dysfunction, while traditional anthropometric measures, such as BMI, have limited ability to assess the risk of erectile dysfunction. Therefore, this study aimed to investigate the association between the new anthropometric index and erectile dysfunction.
A study involving 3594 participants from the National Health and Nutrition Examination Survey was conducted. The study calculated various anthropometric indices such as waist circumference (WC), waist-to-height ratio (WtHR), body mass index (BMI), a body shape index (ABSI), conicity index (CI), and body roundness index (BRI). The relationship between anthropometric indices and erectile dysfunction (ED) was investigated using multivariate logistic regression and restricted cubic splines (RCS). Interaction analysis was conducted on subgroups to confirm the findings. Additionally, the efficacy of various anthropometric indicators in predicting the risk of erectile dysfunction was assessed using the receiver operating characteristic curve (ROC).
After adjusting for potential confounding factors, we identified a positive and independent correlation between erectile dysfunction (ED) and all other anthropometric measures except for BMI. Additionally, the risk of ED increased by 49% and 42% for each standard deviation increment in ABSI and CI, respectively. Dose-response curve analysis demonstrated that WC, BMI, WtHR, and CI displayed a non-linear correlation with the risk of ED. The subgroup analysis revealed that individuals classified as White, who had higher levels of WC, ABSI, and CI, were more susceptible to erectile dysfunction compared to people from other races. ROC analysis showed that ABSI was superior in detecting erectile dysfunction (area under the curve: 0.750; 95% CI 0.732-0.768; optimal cutoff value: 0.083) as compared to other indices. The combination of obesity defined by BMI and other anthropometric measures showed that higher ABSI and CI levels were positively associated with the prevalence of erectile dysfunction, independent of BMI (P < .001).
In this study, anthropometric indicators including ABSI, BRI, WtHR, CI, and WC were positively associated with erectile dysfunction. To improve the prevention and treatment of this condition, it is recommended that new anthropometric indicators receive greater consideration.
目前，越来越多的研究表明肥胖与勃起功能障碍之间存在正相关，而传统的人体测量指标，如体重指数（BMI），评估勃起功能障碍风险的能力有限。因此，本研究旨在探讨新的人体测量指数与勃起功能障碍之间的关联。
对来自美国国家健康与营养检查调查的3594名参与者进行了一项研究。该研究计算了各种人体测量指数，如腰围（WC）、腰高比（WtHR）、体重指数（BMI）、体型指数（ABSI）、锥度指数（CI）和身体圆润度指数（BRI）。使用多变量逻辑回归和受限立方样条（RCS）研究人体测量指数与勃起功能障碍（ED）之间的关系。对亚组进行交互分析以证实研究结果。此外，使用受试者工作特征曲线（ROC）评估各种人体测量指标预测勃起功能障碍风险的效能。
在调整潜在混杂因素后，我们发现勃起功能障碍（ED）与除BMI之外的所有其他人体测量指标之间存在正相关且独立相关。此外，ABSI和CI每增加一个标准差，ED风险分别增加49%和42%。剂量反应曲线分析表明，WC、BMI、WtHR和CI与ED风险呈非线性相关。亚组分析显示，与其他种族的人相比，被归类为白人且WC、ABSI和CI水平较高的个体更容易患勃起功能障碍。ROC分析表明，与其他指数相比，ABSI在检测勃起功能障碍方面更具优势（曲线下面积：0.750；95%可信区间0.732 - 0.768；最佳截断值：0.083）。由BMI定义的肥胖与其他人体测量指标的组合表明，较高的ABSI和CI水平与勃起功能障碍的患病率呈正相关，独立于BMI（P < 0.001）。
在本研究中，包括ABSI、BRI、WtHR、CI和WC在内的人体测量指标与勃起功能障碍呈正相关。为了改善这种疾病的预防和治疗，建议更多地考虑新的人体测量指标。
