Coultas Leigh, Chawengsaksophak Kallayanee, Rossant Janet
The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada.
Nature. 2005 Dec 15;438(7070):937-45. doi: 10.1038/nature04479.
The intricate patterning processes that establish the complex vascular system during development depend on a combination of intrinsic pre-patterning and extrinsic responses to environmental parameters. Mutational studies in mice and fish have shown that the vascular system is highly sensitive to genetic disruption and have identified potential targets for therapeutic interventions. New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stem-cell niches highlight possible side effects of anti-angiogenic therapy and the need for new targets.
在发育过程中建立复杂血管系统的精细模式形成过程依赖于内在预模式和对环境参数的外在反应的结合。对小鼠和鱼类的突变研究表明，血管系统对基因破坏高度敏感，并已确定了治疗干预的潜在靶点。对血管内皮生长因子的非血管作用以及成体器官和干细胞微环境中内皮细胞需求的新见解凸显了抗血管生成治疗可能的副作用以及对新靶点的需求。
