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发育及人类疾病中的淋巴管生成

Lymphangiogenesis in development and human disease.

作者信息

Alitalo Kari, Tammela Tuomas, Petrova Tatiana V

机构信息

Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer, Research, P.O.B. 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

出版信息

Nature. 2005 Dec 15;438(7070):946-53. doi: 10.1038/nature04480.

Abstract

The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence. They have an important role in the pathogenesis of several diseases, such as cancer, lymphoedema and various inflammatory conditions. Recent biological and technological developments in lymphatic vascular biology will lead to a better understanding and treatment of these diseases.

摘要

淋巴管系统形成一个血管网络,该网络从组织中引流组织间液并将其回输到血液中。淋巴管也是机体免疫防御的重要组成部分。它们在几种疾病的发病机制中发挥重要作用,如癌症、淋巴水肿和各种炎症性疾病。淋巴管生物学领域最近的生物学和技术进展将有助于更好地理解和治疗这些疾病。

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