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发育及人类疾病中的淋巴管生成

Lymphangiogenesis in development and human disease.

作者信息

Alitalo Kari, Tammela Tuomas, Petrova Tatiana V

机构信息

Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer, Research, P.O.B. 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

出版信息

Nature. 2005 Dec 15;438(7070):946-53. doi: 10.1038/nature04480.

DOI:10.1038/nature04480
PMID:16355212
Abstract

The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence. They have an important role in the pathogenesis of several diseases, such as cancer, lymphoedema and various inflammatory conditions. Recent biological and technological developments in lymphatic vascular biology will lead to a better understanding and treatment of these diseases.

摘要

淋巴管系统形成一个血管网络,该网络从组织中引流组织间液并将其回输到血液中。淋巴管也是机体免疫防御的重要组成部分。它们在几种疾病的发病机制中发挥重要作用,如癌症、淋巴水肿和各种炎症性疾病。淋巴管生物学领域最近的生物学和技术进展将有助于更好地理解和治疗这些疾病。

相似文献

1
Lymphangiogenesis in development and human disease.发育及人类疾病中的淋巴管生成
Nature. 2005 Dec 15;438(7070):946-53. doi: 10.1038/nature04480.
2
Targeted treatment for lymphedema and lymphatic metastasis.淋巴水肿和淋巴转移的靶向治疗。
Ann N Y Acad Sci. 2008;1131:215-24. doi: 10.1196/annals.1413.019.
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Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.淋巴管系统:发育、分子调控及其在肿瘤转移和炎症中的作用
Trends Immunol. 2004 Jul;25(7):387-95. doi: 10.1016/j.it.2004.05.003.
4
Lymphangiogenesis, inflammation and metastasis.淋巴管生成、炎症与转移
Anticancer Res. 2005 Nov-Dec;25(6C):4503-11.
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Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis.胰腺癌细胞系分泌的血管内皮生长因子-C在肿瘤淋巴管生成的体外模型中促进淋巴管内皮细胞迁移。
Pancreas. 2007 May;34(4):444-51. doi: 10.1097/mpa.0b13e31803dd307.
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Lymphangiogenesis: in vitro and in vivo models.淋巴管生成:体外和体内模型。
FASEB J. 2010 Jan;24(1):8-21. doi: 10.1096/fj.09-132852. Epub 2009 Sep 2.
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Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.淋巴管生成的调控——从细胞命运决定到血管重塑
Exp Cell Res. 2006 Mar 10;312(5):575-83. doi: 10.1016/j.yexcr.2005.10.034. Epub 2005 Dec 15.
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Methods to study lymphatic vessel integrins.研究淋巴管整合素的方法。
Methods Enzymol. 2007;426:415-38. doi: 10.1016/S0076-6879(07)26018-5.
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Molecular control of lymphatic metastasis.淋巴转移的分子调控
Ann N Y Acad Sci. 2008;1131:225-34. doi: 10.1196/annals.1413.020.
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Adventitial lymphatic vessels -- an important role in atherosclerosis.外膜淋巴管——在动脉粥样硬化中起重要作用。
Med Hypotheses. 2007;69(6):1238-41. doi: 10.1016/j.mehy.2007.04.007. Epub 2007 Sep 6.

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