Kantero R L, Wide L, Widholm O
Acta Endocrinol (Copenh). 1975 Jan;78(1):11-21. doi: 10.1530/acta.0.0780011.
In a series of 146 school girls and nurses in the serum levels of growth hormone (GH), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were determined in the afternoon after 4-5 hours' fast. Blood specimens of the menstruating girls were taken on the 7th to 10th day from the beginning of the preceding menstrual bleeding. From the 24-hour urines collected on the previous day the excretion of total oestrogens, 17-ketosteroids and 17-hydrocorticosteroids was determined. The series was grouped according to skeletal age which varied from 8.0 years to the adult stage. In the girls aged 11-13 years the GH curve showed a significant rise parallel with the mean height curve. The FSH values at the early age of 8-9 years corresponded to the follicular phase of adult women. The LH level increased syteeply up to the 15th year of bone age and mean values of adults were found to be about three times those of childhood. The excretion of total oestrogens and 17-ketosteroids increased steadily up to the full maturity of skeletal age. In the oldest group of girls the excretion was about four times that of the group aged 8-9 years. The hormonal maturation seems to continue until late puberty. The 17-OHCS, on the other hand, reached the adult level in the group with a bone age of 13 years. The excretion of 17-OHCS shows a steep rise from the age of 11 to 12 years and this acceleration of excretion perhaps exceeds the increase in surface area.
对146名女学生和护士进行了研究，在禁食4 - 5小时后的下午测定她们血清中的生长激素（GH）、促卵泡激素（FSH）和促黄体生成素（LH）水平。月经初潮女孩的血样于上次月经出血开始后的第7至10天采集。测定前一天收集的24小时尿液中总雌激素、17 - 酮类固醇和17 - 羟皮质类固醇的排泄量。该组研究对象根据骨骼年龄分组，骨骼年龄从8.0岁到成年期不等。在11 - 13岁的女孩中，GH曲线显示出与平均身高曲线平行的显著上升。8 - 9岁低龄女孩的FSH值与成年女性的卵泡期相当。LH水平在骨龄达到15岁之前急剧上升，发现成年人的平均值约为儿童时期的三倍。总雌激素和17 - 酮类固醇的排泄量在骨骼年龄完全成熟之前稳步增加。在年龄最大的女孩组中，排泄量约为8 - 9岁组的四倍。激素成熟似乎一直持续到青春期后期。另一方面，17 - OHCS在骨龄为13岁的组中达到成人水平。17 - OHCS的排泄量从11岁到12岁急剧上升，这种排泄加速可能超过了体表面积的增加。
