甲状腺功能减退症中环磷酸腺苷的蓄积。大鼠脂肪细胞对去甲肾上腺素的敏感性降低。

Accumulation of cyclic AMP in hypothyroidism. Decreased sensitivity to norepinephrine in rat adipocytes.

作者信息

Grill V, Rosenquist U

出版信息

Acta Endocrinol (Copenh). 1975 Jan;78(1):39-43. doi: 10.1530/acta.0.0780039.

DOI:10.1530/acta.0.0780039

Abstract

The effect of hypothyroidism on the noradrenaline-induced accumulation of 3H-cyclic-AMP was measured in rat epididymal adipose tissue. Adipocytes from hypothyroid animals showed a decreased response to noradrenaline 0.02-0.2 times 10-5 m, while higher concentrations of the catecholamine seemed to elicit the same response in cells obtained from euthyroid or hypothyroid animals. The diminished sensitivity to noradrenaline was unaltered after the addition of phentolamine. It is suggested that thyroid hormones modulate the catecholamine-induced lipolytic response at least partly through the adenyl cyclase cyclic-AMP system.

摘要

在大鼠附睾脂肪组织中测定了甲状腺功能减退对去甲肾上腺素诱导的3H-环磷酸腺苷积累的影响。甲状腺功能减退动物的脂肪细胞对0.02 - 0.2×10⁻⁵m的去甲肾上腺素反应降低，而更高浓度的儿茶酚胺似乎在甲状腺功能正常或甲状腺功能减退动物的细胞中引发相同反应。添加酚妥拉明后，对去甲肾上腺素的敏感性降低未改变。提示甲状腺激素至少部分通过腺苷酸环化酶-环磷酸腺苷系统调节儿茶酚胺诱导的脂解反应。