Costa P, Agrò C, Gulotta G, Papa G, Piazza F, Ronga F, Sparacia B, Sansone A
Istituto di Anestesiologia, Rianimazione e dell'Emergenza, Università degli Studi di Palermo.
Minerva Anestesiol. 1992 May;58(5):301-10.
The authors describe the results obtained treating with amrinone for 48 hours 11 patients with acute heart failure. The patients (4 males and 7 females), age range between 50 and 82 years) received an initial bolus of 0.75 mg/kg followed by and infusion which on average was of 5.82 +/- 1.06 (SD) micrograms/kg/min. Besides a subjective and objective clinical improvement they could observe a quick and remarkable improvement of the main hemodynamic parameters (cardiac index, cardiac output, pulmonary capillary wedge pressure, mean pulmonary pressure). The tolerability of the drug was good, except for a decrease in platelet, already described in literature. In conclusion, the Authors consider amrinone a very interesting drug for its positive inotropic and vasodilating activity and because it does not cause an increase of the myocardial oxygen consumption.
作者描述了对11例急性心力衰竭患者使用氨力农治疗48小时所获得的结果。这些患者（4名男性和7名女性，年龄在50至82岁之间）首先静脉推注0.75毫克/千克，随后进行平均为5.82±1.06（标准差）微克/千克/分钟的输注。除了主观和客观的临床改善外，他们还观察到主要血流动力学参数（心脏指数、心输出量、肺毛细血管楔压、平均肺动脉压）迅速且显著改善。药物耐受性良好，除了血小板减少外，这在文献中已有描述。总之，作者认为氨力农因其正性肌力和血管舒张活性且不引起心肌氧耗增加，是一种非常有吸引力的药物。
