Auffret Michel, Rousseau Sabrina, Boutet Isabelle, Tanguy Arnaud, Baron Jacques, Moraga Dario, Duchemin Matthieu
Laboratoire des Sciences de l'Environnement Marin, UMR CNRS 6539-LEMAR, Technopôle Brest-Iroise, 29280 Plouzane, France.
Ecotoxicol Environ Saf. 2006 Mar;63(3):393-405. doi: 10.1016/j.ecoenv.2005.10.016. Epub 2005 Dec 13.
As a part of the multidisciplinary program Biological Effects of Environmental Pollution in Marine Coastal Ecosystems of the European Commission, this study aimed to validate immunological alterations as biomarkers of exposure to chemical contamination in polluted areas of Western Mediterranea. The status of the immune system has been assessed in mussels (Mytilus galloprovincialis) by measuring several immunopathological and immunocompetence parameters. Alterations of total hemocyte counts, lysosomal stability, and phagocytosis were among the most reliable effects observed in polluted sites and suggested immunosuppressive conditions in contaminated mussels. An immunotoxicological index was calculated from the set of individual data. By providing a single value per sampling station to score immunological alterations in mussels, this novel approach allowed recognition of a gradient of perturbation correlated to pollution intensity in two of the three sites monitored. Processing a set of biological parameters by this method was found to increase the ecotoxicological relevance of such multiparametric studies for the assessment of chemical contamination in coastal waters.
作为欧盟委员会“海洋沿岸生态系统环境污染的生物效应”多学科项目的一部分，本研究旨在验证免疫改变作为西地中海污染区域化学污染暴露生物标志物的有效性。通过测量几个免疫病理学和免疫能力参数，对贻贝（Mytilus galloprovincialis）的免疫系统状况进行了评估。总血细胞计数、溶酶体稳定性和吞噬作用的改变是在污染地点观察到的最可靠的效应之一，表明受污染贻贝存在免疫抑制情况。根据一组个体数据计算了免疫毒理学指数。通过为每个采样站提供一个单一值来对贻贝的免疫改变进行评分，这种新方法能够识别出在三个监测地点中的两个地点与污染强度相关的扰动梯度。发现通过这种方法处理一组生物学参数可以提高此类多参数研究在评估沿海水域化学污染方面的生态毒理学相关性。
