Wahlsten D, Ozaki H S, Livy D
Department of Psychology, University of Alberta, Edmonton, Canada.
Neurosci Lett. 1992 Feb 17;136(1):99-101. doi: 10.1016/0304-3940(92)90657-s.
The mouse strain ddN from Japan was crossed with three other inbred strains prone to absence of the corpus callosum (BALB/cWah1, I/LnJ and 129/ReJ), and at least one brain with abnormally small corpus callosum was observed in offspring from each F1 hybrid cross. Data for several polymorphic protein markers revealed that the four strains are not closely related genetically. Nevertheless, they share common genetic causes of an absent corpus callosum, which helps to understand why anatomical studies of ddN and BALB/c have yielded similar results. The hippocampal commissure is abnormally small in I/LnJ mice and the anterior commissure is often malformed in BALB/c mice, but both commissures in hybrids were normal, which suggests a different genetic basis for these defects and the absent corpus callosum.
来自日本的ddN小鼠品系与其他三种易出现胼胝体缺失的近交系（BALB/cWah1、I/LnJ和129/ReJ）进行杂交，在每个F1杂交后代中均观察到至少一个胼胝体异常小的大脑。几种多态性蛋白质标记的数据显示，这四个品系在遗传上没有密切关系。然而，它们存在胼胝体缺失的共同遗传原因，这有助于理解为什么对ddN和BALB/c的解剖学研究得出了相似的结果。I/LnJ小鼠的海马连合异常小，而BALB/c小鼠的前连合常常畸形，但杂交后代中的这两种连合均正常，这表明这些缺陷和胼胝体缺失具有不同的遗传基础。
