Bengner T, Malina T, Lindenau M, Voges B, Goebell E, Stodieck S
Epilepsy Center Hamburg, Protestant Hospital Alsterdorf, Hamburg, Germany.
Epilepsy Behav. 2006 Feb;8(1):220-7. doi: 10.1016/j.yebeh.2005.10.009. Epub 2005 Dec 13.
Proactive interference (PI) decreases short- and long-term memory in healthy subjects. Neurological patients exhibit a heightened PI effect on short-term memory. It is, however, not known if PI affects long-term memory in neurological patients. We analyzed whether epilepsy heightens the negative effect of PI on long-term face memory. PI was induced by a list of 20 faces learned 24 hours prior to a target list of 20 faces. We tested immediate and 24-hour recognition for both lists. Twelve healthy controls and 42 patients with generalized epilepsy or temporal lobe epilepsy (TLE) were studied. PI led to a decrease in 24-hour recognition in patients with generalized epilepsy and TLE but not in controls. Thus, PI may cause long-term memory disturbances in epilepsy patients. PI was also associated with decreased short-term memory, but only in right TLE. This confirms the dominant role of the right temporal lobe in short-term face memory.
前摄干扰（PI）会降低健康受试者的短期和长期记忆。神经疾病患者在短期记忆方面表现出更强的前摄干扰效应。然而，目前尚不清楚前摄干扰是否会影响神经疾病患者的长期记忆。我们分析了癫痫是否会增强前摄干扰对长期面部记忆的负面影响。前摄干扰是由在学习20张目标面孔列表之前24小时学习的20张面孔列表诱发的。我们测试了两个列表的即时识别和24小时后的识别。研究了12名健康对照者和42名全身性癫痫或颞叶癫痫（TLE）患者。前摄干扰导致全身性癫痫和颞叶癫痫患者24小时后的识别率下降，但对照者未出现这种情况。因此，前摄干扰可能会导致癫痫患者出现长期记忆障碍。前摄干扰还与短期记忆下降有关，但仅在右侧颞叶癫痫患者中出现。这证实了右侧颞叶在短期面部记忆中的主导作用。
