Tectonic，一种刺猬信号通路的新型调节因子，激活和抑制过程均需要它。
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
作者信息
Reiter Jeremy F, Skarnes William C
机构信息
Developmental and Stem Cell Biology Program, and Diabetes Center, University of California, San Francisco, 94143-0525, USA.
出版信息
Genes Dev. 2006 Jan 1;20(1):22-7. doi: 10.1101/gad.1363606. Epub 2005 Dec 15.
Abstract
We report the identification of a novel protein that participates in Hedgehog-mediated patterning of the neural tube. This protein, named Tectonic, is the founding member of a previously undescribed family of evolutionarily conserved secreted and transmembrane proteins. During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Epistasis analyses reveal that Tectonic modulates Hh signal transduction downstream of Smoothened (Smo) and Rab23. Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity.
摘要
我们报告了一种新型蛋白质的鉴定，该蛋白质参与刺猬索尼克（Hedgehog）介导的神经管模式形成。这种名为构造蛋白（Tectonic）的蛋白质是一个先前未描述的进化保守的分泌和跨膜蛋白家族的创始成员。在神经管发育过程中，小鼠构造蛋白对于最腹侧细胞类型的形成以及刺猬索尼克（Hh）信号通路的完全激活是必需的。上位性分析表明，构造蛋白在平滑基因（Smo）和Rab23的下游调节Hh信号转导。有趣的是，构造蛋白与刺猬索尼克（Shh）和构造蛋白与平滑基因（Smo）双突变体的特征表明，构造蛋白在抑制Hh信号通路活性方面发挥了额外作用。
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