Furuya E Yoko, Lowy Franklin D
Division of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians & Surgeons, 630 West 168th Street, New York, New York 10032, USA.
Nat Rev Microbiol. 2006 Jan;4(1):36-45. doi: 10.1038/nrmicro1325.
Over the past decade, antimicrobial resistance has emerged as a major public-health crisis. Common bacterial pathogens in the community such as Streptococcus pneumoniae have become progressively more resistant to traditional antibiotics. Salmonella strains are beginning to show resistance to crucial fluoroquinolone drugs. Community outbreaks caused by a resistant form of Staphylococcus aureus, known as community-associated meticillin (formerly methicillin)-resistant Staphylococcus aureus, have caused serious morbidity and even deaths in previously healthy children and adults. To decrease the spread of such antimicrobial-resistant pathogens in the community, a greater understanding of their means of emergence and survival is needed.
在过去十年中,抗生素耐药性已成为一个重大的公共卫生危机。社区中的常见细菌病原体,如肺炎链球菌,对传统抗生素的耐药性已逐渐增强。沙门氏菌菌株开始对关键的氟喹诺酮类药物表现出耐药性。一种耐药形式的金黄色葡萄球菌,即社区相关性耐甲氧西林金黄色葡萄球菌,引发的社区疫情已在原本健康的儿童和成人中导致严重发病甚至死亡。为了减少此类耐药病原体在社区中的传播,需要更深入地了解它们的出现和生存方式。