小肽催化的水中直接不对称羟醛反应。
The small peptide-catalyzed direct asymmetric aldol reaction in water.
作者信息
Dziedzic Pawel, Zou Weibiao, Háfren Jonas, Córdova Armando
机构信息
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
出版信息
Org Biomol Chem. 2006 Jan 7;4(1):38-40. doi: 10.1039/b515880j. Epub 2005 Nov 22.
DOI:10.1039/b515880j
PMID:16357992
Abstract
Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding beta-hydroxy ketones with up to 86% ee in water and 99% ee in aqueous media.
摘要
在N端带有伯胺的简单模块化二肽和三肽，能催化未修饰的酮与醛之间的水相不对称羟醛反应，在水中生成相应的β-羟基酮，对映体过量值（ee）高达86%，在水相介质中ee值可达99%。
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