五氟苯基（PFP）磺酸盐对二甲基精氨酸二甲胺水解酶（DDAH）和精氨酸脱亚氨酶（ADI）的抑制作用。
Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.
作者信息
Vallance Patrick, Bush Hannah D, Mok B James, Hurtado-Guerrero Ramon, Gill Herpreet, Rossiter Sharon, Wilden Jonathan D, Caddick Stephen
机构信息
Department of Medicine, Rayne Building, 5 University Street London, WC1E 6JJ, UK.
出版信息
Chem Commun (Camb). 2005 Nov 28(44):5563-5. doi: 10.1039/b510709a. Epub 2005 Oct 11.
DOI:10.1039/b510709a
PMID:16358064
Abstract
A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.
摘要
一系列由五氟苯乙烯磺酸酯与各种硝酮反应得到的五氟苯基（PFP）磺酸酯对细菌酶二甲基精氨酸二甲胺水解酶（DDAH）和精氨酸脱亚氨酶（ADI）具有显著的抑制活性。
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