Alves Maria Lúcia D'Arbo, Maciel Rui M de Barros, Kunii Ilda, Iazigi Nassim
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto, SP.
Arq Bras Endocrinol Metabol. 2005 Aug;49(4):516-20. doi: 10.1590/s0004-27302005000400008. Epub 2005 Oct 19.
The safest and most efficient way to diagnose congenital hypothyroidism (CH) is through screening programs using serum thyroid stimulating hormone (TSH). CH occurs in one in 1:2,300-1:5,000 births but higher rates are found in iodine-deficient areas. Iodine was measured in the urine of 141 newborns (87 males and 54 females) from Ribeirão Preto to complement the screening program developed by the School of Medicine of Ribeirão Preto (FMRP-USP) and Federal University of São Paulo (UNIFESP). TSH values did not disclose any case of CH, although we have seen an elevated ratio (0.96%) of calls for retests. The iodine urinary levels ranged from 2.1 to 194 microg/l (mean 58.3+/-36.2 microg/l). No differences between the levels of urinary iodine and gender or gestational ages were observed. A negative correlation between urinary iodine and TSH of blood from umbilical cord was found (r= -0.20, p= 0.02).
诊断先天性甲状腺功能减退症（CH）最安全、最有效的方法是通过使用血清促甲状腺激素（TSH）的筛查项目。CH的发病率为1/2300 - 1/5000，但在缺碘地区发病率更高。对来自里贝朗普雷图的141名新生儿（87名男性和54名女性）的尿液进行碘含量检测，以补充由里贝朗普雷图医学院（FMRP-USP）和圣保罗联邦大学（UNIFESP）开展的筛查项目。TSH值未显示出任何CH病例，尽管我们发现复查要求的比例有所升高（0.96%）。尿碘水平在2.1至194微克/升之间（平均58.3±36.2微克/升）。未观察到尿碘水平在性别或胎龄之间存在差异。发现尿碘与脐带血TSH之间存在负相关（r = -0.20，p = 0.02）。
