Gidding S S, Benson D W, Clark E B, Rocchini A P
Division of Cardiology, Children's Memorial Hospital, Chicago, IL 60614.
Pediatr Res. 1992 Jul;32(1):10-6. doi: 10.1203/00006450-199207000-00002.
We assessed pediatric cardiology research by reviewing pediatric cardiology abstracts submitted in 1990 to the Society of Pediatric Research, American Academy of Pediatrics, and American Heart Association national meetings. Included were accepted and rejected studies. Abstracts were reviewed for disease being studied, methodology used to answer the research question, study design, and acceptance/rejection. Abstracts were analyzed from 123 institutions, 81 American and 42 foreign. Out of 423 abstracts, 307 (72.6%) were clinical and the remainder were basic science investigations. Slightly more than half of the clinical submissions were related to congenital heart disease. Coronary artery disease and inflammatory diseases accounted for 12% of clinical submissions. Echocardiography, clinical outcome measures, and electrophysiology were the most common research methodologies. Almost 80% of basic science research was performed in normal tissues; animal physiology, fetal physiology, and cellular/biochemical studies were the most common methodologies. With regard to study design, half of the clinical studies were retrospective and only 6% were either prospective epidemiologic or prospective controlled intervention trials. For basic sciences, 38% of abstracts were descriptions of phenomena and 62% were hypothesis testing, with developmental hypotheses being most common. Acceptance rates favored higher quality study design. However, areas of greatest interest to cardiologists, congenital heart disease, cardiomyopathy, and electrophysiology, had poorer quality study design than did other areas. We have shown broad interest in pediatric cardiology research. However, clinical studies frequently were retrospective or had uncontrolled study designs. Basic science research was performed at a small number of institutions and emphasized either description of phenomena or developmental biology of normal tissues.
我们通过回顾1990年提交给儿科研究学会、美国儿科学会和美国心脏协会全国会议的儿科心脏病学摘要，对儿科心脏病学研究进行了评估。纳入的研究包括被接受和被拒绝的研究。对摘要进行了审查，内容包括所研究的疾病、用于回答研究问题的方法、研究设计以及接受/拒绝情况。对来自123个机构的摘要进行了分析，其中81个来自美国，42个来自国外。在423篇摘要中，307篇（72.6%）为临床研究，其余为基础科学研究。略多于一半的临床研究提交与先天性心脏病有关。冠状动脉疾病和炎症性疾病占临床研究提交的12%。超声心动图、临床结局指标和电生理学是最常见的研究方法。几乎80%的基础科学研究是在正常组织中进行的；动物生理学、胎儿生理学以及细胞/生物化学研究是最常见的方法。关于研究设计，一半的临床研究是回顾性的，只有6%是前瞻性流行病学或前瞻性对照干预试验。对于基础科学，38%的摘要为现象描述，62%为假设检验，其中发育假设最为常见。接受率倾向于高质量的研究设计。然而，心脏病学家最感兴趣的领域，即先天性心脏病、心肌病和电生理学，其研究设计质量比其他领域要差。我们已经表明对儿科心脏病学研究有广泛兴趣。然而，临床研究经常是回顾性的或具有非对照的研究设计。基础科学研究在少数机构进行，并且侧重于现象描述或正常组织的发育生物学研究。
