Siwek Marcin, Wróbel Andrzej, Dudek Dominika, Nowak Gabriel, Zieba Andrzej
Klinika Psychiatrii Dorosłych CM UJ.
Psychiatr Pol. 2005 Sep-Oct;39(5):911-20.
Magnesium and copper are important modulators of NMDA-receptor activity. Recent data indicate that disturbances of glutamatergic transmission (especially via NMDA-receptor) are involved in pathogenesis of mood disorders. Magnesium deficiency, the same as disturbances in turn over of copper, are related to a variety of psychological symptoms especially depression. There are many reports indicating significant changes in blood levels of magnesium or copper during a depressive episode. Moreover magnesium exhibits antidepressant-like and anxiolytic-like effects in animal models of depression, in rodents. This article reviews the alterations in central and peripheral magnesium and copper homeostasis in relation to pathophysiology and treatment of depression.
镁和铜是N-甲基-D-天冬氨酸受体（NMDA受体）活性的重要调节剂。最近的数据表明，谷氨酸能传递障碍（尤其是通过NMDA受体）参与了情绪障碍的发病机制。镁缺乏与铜代谢紊乱一样，与多种心理症状尤其是抑郁有关。有许多报告表明，在抑郁发作期间，血液中镁或铜的水平会发生显著变化。此外，在啮齿动物的抑郁症动物模型中，镁表现出抗抑郁样和抗焦虑样作用。本文综述了中枢和外周镁和铜稳态的改变与抑郁症病理生理学和治疗的关系。
