Głuszek S, Matykiewicz J
Department of General, Oncological and Casualty Surgery, The Municipal Hospital in Kielce & Institute of Medical Education, Swietokrzyska Academy in Kielce, Poland.
Rocz Akad Med Bialymst. 2005;50:224-9.
To perform a comparative study of two types of vagotomy: trunctal vagotomy (TV) and highly selective vagotomy (HSV) effects on pancreatic morphology assessed with light microscope and ultrastructural changes assessed with electron microscope in rabbits 30, 90 and 180 days after the vagotomy.
The experiments were carried out on 89 male Popielno white rabbits, aged 4-6 months, 2.5 to 3.0 kg of body weight. On the 30th, 90th and 180th day after the vagotomy, rabbits were sacrificed and the pancreases were taken for the light and electron microscopic evaluation.
The regressive changes coexisting with adaptive like renewal of epithelial cells and mild interstitial fibrosis resulting from vagotomy were more pronounced in the early post-operative period and tended to normalize in the later post-operative one. All the changes seen in post-operative period were more prominent after TV than after HSV.
Both truncal and highly selective vagotomy affects evidently the morphology and ultrastructure of the pancreas in rabbits however the changes after the first procedure were more advanced than after the latter one. The intensity of the changes is highest early after these operations and tend to normalize in the later post-operative period.
对两种类型的迷走神经切断术进行比较研究，即经腹迷走神经切断术（TV）和高选择性迷走神经切断术（HSV），观察其对家兔迷走神经切断术后30天、90天和180天胰腺形态的影响，并用光学显微镜评估，同时用电子显微镜评估超微结构变化。
实验在89只4至6个月大、体重2.5至3.0千克的雄性波皮耶尔诺白兔身上进行。在迷走神经切断术后第30天、90天和180天，处死家兔并取出胰腺进行光学和电子显微镜评估。
迷走神经切断术后出现的退行性变化与上皮细胞适应性更新及轻度间质纤维化同时存在，在术后早期更为明显，且在术后后期趋于正常。术后观察到的所有变化在经腹迷走神经切断术后比高选择性迷走神经切断术后更显著。
经腹迷走神经切断术和高选择性迷走神经切断术均明显影响家兔胰腺的形态和超微结构，然而第一种手术方式后的变化比第二种更严重。这些手术术后早期变化强度最高，且在术后后期趋于正常。
