Głuszek S, Matusiewicz J
Department of General Surgery, Ministry of Internal Affairs Hospital, Kielce, Poland.
Mater Med Pol. 1993 Jan-Mar;25(1):27-31.
The purpose of the study was evaluation of morphological changes in canine pancreas on days 30, 90 and 180 after truncal vagotomy (VT) and highly selective vagotomy (HSV). On the 30th day after VT in some cells zymogen granules and lysosomes were disintegrated, vacuolization was moderately expressed, and fibrosis was present in the exocrine part. On the 30th day after HSV the structure of the exocrine part showed no important changes, but in the endocrine part in about one-third of cells in the islets deformed nuclei and trinucleated cells were found, along with changes of mitochondrial structure. beta cells contained very numerous insulin-containing granules. On the 90th day some changes observed on the 30th day after VT or HSV were no longer seen. On the 180th day after HSV the EM changes were negligible, less intense than after VT. The electron microscopic changes after VT and HSV were most pronounced early after the operation, particularly after VT. In later stages of the experiment a part of the changes regressed, but then more structural changes were seen after VT than after HSV.
本研究的目的是评估犬在进行迷走神经干切断术（VT）和高选择性迷走神经切断术（HSV）后第30天、90天和180天胰腺的形态学变化。VT术后第30天，一些细胞中的酶原颗粒和溶酶体解体，空泡化中度表达，外分泌部出现纤维化。HSV术后第30天，外分泌部结构无重要变化，但在内分泌部，约三分之一的胰岛细胞中发现核变形和三核细胞，同时线粒体结构也发生改变。β细胞含有大量含胰岛素颗粒。VT或HSV术后第30天观察到的一些变化在第90天不再出现。HSV术后第180天，电镜下变化可忽略不计，比VT术后的变化程度轻。VT和HSV术后的电镜变化在术后早期最为明显，尤其是VT术后。在实验后期，部分变化有所消退，但之后VT术后出现的结构变化比HSV术后更多。
