Simmer H H, Frankland M, Greipel M
Am J Obstet Gynecol. 1975 Mar 1;121(5):646-52. doi: 10.1016/0002-9378(75)90468-8.
In studying the mechanisms which govern estriol production in human pregnancy at term, 16 alpha OH-DHEA, 16alpha-OH-DHEA sulfate, and unbound unconjugated cortisol were measured in peripheral venous plasma of 28 healthy women and in cord venous and arterial plasms of their newborn infants at the time of elective cesarean section prior to the onset of labor. In eight cases treated with 150 mg. of cortisol, maternal and cord plasma 16alpha-OH-DHEA and its sulfate were considerably lower than in 10 control cases. Approximately 4 to 8 1/2 hours after injection of 40 I.U. of Depot-ACTH, both of these estriol precursors were also significantly decreased. It is concluded from these experiments that cortisol causes a decrease of estriol mainly by suppressing fetal 16alpha-OH-DS.
在研究足月妊娠时人体雌三醇产生的调控机制过程中，对28名健康女性的外周静脉血浆以及她们的新生儿在择期剖宫产且分娩尚未开始时的脐静脉和动脉血浆中的16α-OH-DHEA、16α-OH-DHEA硫酸盐和未结合的游离皮质醇进行了测定。在8例接受150毫克皮质醇治疗的病例中，母体和脐带血浆中的16α-OH-DHEA及其硫酸盐显著低于10例对照病例。注射40国际单位长效促肾上腺皮质激素后约4至8个半小时，这两种雌三醇前体也显著减少。从这些实验得出的结论是，皮质醇主要通过抑制胎儿16α-OH-DS导致雌三醇减少。
