Levine S, Sowinski R, Hoenig E M
Am J Pathol. 1975 Feb;78(2):319-32.
Large, eosinophilic, nonglycogenic nuclear inclusions were produced in the central nervous system by the drug tilorone. At the light microscope level, the inclusions occurred predominantly in astrocytes. Ultrastructurally, they were identical to the nuclear bodies described in many cell types under many conditions. The bodies were produced by tilorone in small numbers in the median eminence, a part of the hypothalamus that lacks a blood-brain barrier. They were produced in only 2 or 3 days in large numbers adjacent to zones of thermal or traumatic necrosis or in areas of inflammation. These facts, and the distribution of affected astrocytes, indicated that permeability factors and cerebrospinal fluid flow were involved in the development of the nuclear bodies. The large size and large number of nuclear bodies produced by tilorone should facilitate studies of this poorly understood nuclear organelle.
药物替洛隆可在中枢神经系统中产生大的、嗜酸性的、非糖原性核内包涵体。在光学显微镜水平，这些包涵体主要出现在星形胶质细胞中。在超微结构上，它们与在许多条件下许多细胞类型中描述的核体相同。在缺乏血脑屏障的下丘脑的一部分——正中隆起中，替洛隆少量产生这些核体。在热坏死或创伤坏死区域附近或炎症区域，仅在2或3天内就大量产生这些核体。这些事实以及受影响星形胶质细胞的分布表明，通透性因子和脑脊液流动参与了核体的形成。替洛隆产生的大尺寸和大量核体应有助于对这种了解甚少的核细胞器进行研究。
