Rubin B P
Department of Anatomic Pathology, University of Washington Medical Center, 1959 NE Pacific Street, Box 356100, Seattle, WA 98195, USA.
Histopathology. 2006 Jan;48(1):83-96. doi: 10.1111/j.1365-2559.2005.02291.x.
Recently, there has been intense interest in the study of gastrointestinal stromal tumour (GIST); one might call it a virtual GIST revolution. This is due largely to the realization that most GISTs express KIT and harbour activating c-KIT (KIT) or platelet-derived growth factor receptor-alpha (PDGFRA) receptor tyrosine kinase mutations that can be targeted by small molecule pharmacological inhibitors. Pathologists have benefited greatly from this revolution, mainly in the form of an improved ability to classify GISTs and, even more recently, in understanding the molecular underpinnings that underlie many fascinating clinical and pathological correlations. It is the purpose of this review to summarize recent developments in GIST classification and the molecular pathogenesis of GIST.
最近，胃肠道间质瘤（GIST）的研究引起了广泛关注；可以说这是一场名副其实的GIST革命。这主要是因为人们认识到，大多数GIST表达KIT，并携带激活型c-KIT（KIT）或血小板衍生生长因子受体α（PDGFRA）受体酪氨酸激酶突变，这些突变可被小分子药理抑制剂靶向作用。病理学家从这场革命中受益匪浅，主要体现在对GIST进行分类的能力有所提高，以及最近在理解许多引人入胜的临床和病理相关性背后的分子基础方面。本综述的目的是总结GIST分类和GIST分子发病机制的最新进展。
