健康志愿者纹状体多巴胺D2/D3受体可用性与言语智商之间的相关性。
The correlation between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient in healthy volunteers.
作者信息
Guo Jin Fu, Kuang Yang Yen, Tsing Chiu Nan, Lieh Yeh Tzung, See Chen Po, Lee I Hui, Lin Chu Ching
机构信息
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
Psychol Med. 2006 Apr;36(4):547-54. doi: 10.1017/S0033291705006732. Epub 2005 Dec 19.
BACKGROUND
Although a correlation between the central dopaminergic system and intelligence may exist, the results from imaging studies remain inconclusive. The aim of this study was to explore the relationship between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient (VIQ) using single photon emission computed tomography (SPECT).
METHOD
Striatal D2/D3 receptor availability of 64 healthy subjects was determined with the [123I]iodobenzamide ([123I]IBZM) ligand. Intelligence quotients (IQs) of the subjects were measured by the Wechsler Adult Intelligence Scale--Revised (WAIS-R).
RESULTS
In addition to age, left striatal D2/D3 receptor availability correlated positively with VIQ. In females, left striatal D2/D3 receptor availability was the only variable that correlated significantly with the similarities subtest of VIQ.
CONCLUSIONS
There is a relationship between left striatal D2/D3 receptor availability and verbal intelligence, which varies, predominantly in males.
背景
尽管中枢多巴胺能系统与智力之间可能存在关联，但影像学研究结果仍无定论。本研究旨在使用单光子发射计算机断层扫描（SPECT）探索纹状体多巴胺D2/D3受体可用性与言语智商（VIQ）之间的关系。
方法
使用[123I]碘苄酰胺（[123I]IBZM）配体测定64名健康受试者的纹状体D2/D3受体可用性。受试者的智商（IQ）通过韦氏成人智力量表修订版（WAIS-R）进行测量。
结果
除年龄外，左侧纹状体D2/D3受体可用性与VIQ呈正相关。在女性中，左侧纹状体D2/D3受体可用性是与VIQ相似性子测验显著相关的唯一变量。
结论
左侧纹状体D2/D3受体可用性与言语智力之间存在关系，这种关系存在差异，主要体现在男性中。
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