Matteo Maria, Caroppo Ettore, Gliozheni Orion, Carone Domenico, Schonauer Luca Maria, Vizziello Giovanni, Greco Pantaleo, D'Amato Giuseppe
Operative Unit of Obstetric and Gynecology, Department of Surgical Sciences, University of Foggia, Foggia, Italy.
Eur J Obstet Gynecol Reprod Biol. 2006 May 1;126(1):77-80. doi: 10.1016/j.ejogrb.2005.09.018. Epub 2005 Dec 15.
OBJECTIVE(S): The objective was to evaluate the duration of pituitary desensitization after the administration of 3.5 mg of triptorelin (T) and leuprolin (L) depot preparations in patients with endometriosis.
Two groups of 30 patients received, on 21st day of the cycle, 3.75 mg i.m. of triptorelin (T group), and of leuprolin acetate (L group). From the first to the eighth week following gonadotrophin-releasing hormone agonists (GnRH-a) administration both groups underwent pelvic ultrasound and serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) evaluation. Statistical analysis was performed using the ANOVA test and the median test. A p-value < 0.05 was considered significant.
Pituitary suppression was achieved from two to six and from two to seven weeks after the administration of 3.75 mg of leuprolin and triptorelin, respectively. FSH and LH serum levels were significantly higher in the L group than in the T group after the fourth week.
Leuprolin and triptorelin depots (3.75 mg) promote satisfactory ovarian suppression lasting for six and seven weeks, respectively, after administration, with significantly different ambient levels of endogenous LH.
评估3.5毫克曲普瑞林（T）和亮丙瑞林（L）长效制剂给药后子宫内膜异位症患者垂体脱敏的持续时间。
两组各30例患者在月经周期第21天接受3.75毫克曲普瑞林（T组）和醋酸亮丙瑞林（L组）的肌肉注射。在给予促性腺激素释放激素激动剂（GnRH-a）后的第一至第八周，两组均接受盆腔超声检查以及血清促卵泡生成素（FSH）、促黄体生成素（LH）和雌二醇（E2）的评估。采用方差分析检验和中位数检验进行统计分析。p值<0.05被认为具有统计学意义。
分别在给予3.75毫克亮丙瑞林和曲普瑞林后的两至六周和两至七周实现了垂体抑制。第四周后，L组的FSH和LH血清水平显著高于T组。
亮丙瑞林和曲普瑞林长效制剂（3.75毫克）给药后分别可促进持续六至七周的满意的卵巢抑制，内源性LH的周围水平存在显著差异。
