卵巢癌患者术前血清血小板生成素水平高于良性囊肿患者。
Preoperative serum thrombopoietin levels are higher in patients with ovarian cancer than with benign cysts.
作者信息
Tsukishiro Sami, Suzumori Nobuhiro, Nishikawa Hiroshi, Arakawa Atsushi, Suzumori Kaoru
机构信息
Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):67-70. doi: 10.1016/j.ejogrb.2005.10.037. Epub 2005 Dec 15.
OBJECTIVE
To assess the diagnostic relevance of serum thrombopoietin (TPO) levels, we compared serum TPO levels between the patients with ovarian cancer and benign ovarian cysts. We also correlated serum TPO concentrations in ovarian cancer patients to know prognostic factors such as disease stage, tumor grade, histological subtype, and residual tumor mass.
STUDY DESIGN
Preoperative serum TPO levels were measured in women with epithelial ovarian cancer (n=51) and women with benign ovarian cysts (n=25) using an enzyme-linked immunosorbent assay.
RESULTS
The serum TPO concentration was significantly elevated in the ovarian cancer patients as compared to the benign patient controls. Platelet counts and TPO in the serum did not correlate in the ovarian cancer patients. However, using a TPO cutoff of 90 pg/ml and a CA125 cutoff of 30 units/ml, when both markers were elevated, the specificity was as high as 92%.
CONCLUSION
Serum TPO concentrations may have a role in the diagnostic clinical setting for discerning benign from malignant ovarian tumors.
目的
为评估血清血小板生成素（TPO）水平的诊断相关性，我们比较了卵巢癌患者与卵巢良性囊肿患者的血清TPO水平。我们还对卵巢癌患者的血清TPO浓度进行关联分析，以了解疾病分期、肿瘤分级、组织学亚型和残留肿瘤大小等预后因素。
研究设计
采用酶联免疫吸附测定法测量了上皮性卵巢癌患者（n = 51）和卵巢良性囊肿患者（n = 25）术前的血清TPO水平。
结果
与良性对照患者相比，卵巢癌患者的血清TPO浓度显著升高。卵巢癌患者血清中的血小板计数与TPO不相关。然而，当TPO临界值为90 pg/ml且CA125临界值为30 U/ml时，若两种标志物均升高，则特异性高达92%。
结论
血清TPO浓度在鉴别卵巢良恶性肿瘤的诊断临床环境中可能具有一定作用。
Zotero 插件