Scalia Santo, Tursilli Rosanna, Bianchi Anna, Nostro Pierandrea Lo, Bocci Eugenio, Ridi Francesca, Baglioni Piero
Department of Pharmaceutical Sciences, University of Ferrara, via Fossato di Mortara, 44100 Ferrara, Italy.
Int J Pharm. 2006 Feb 3;308(1-2):155-9. doi: 10.1016/j.ijpharm.2005.11.007. Epub 2005 Dec 15.
The aim of the study was to investigate the incorporation of the sunscreen agent, octyl methoxycinnamate into cyclodextrin cavities covalently bound to cloth fibres. Tencel, a cellulosic fabric, was grafted with beta-cyclodextrin molecules through reaction with monochlorotriazinyl-beta-cyclodextrin (beta-CDMCT). The finished and untreated textiles were soaked in water-methanol mixtures containing 2% (v/v) of sunscreen agent and subsequently subjected to several washing cycles. The unmodified and modified fabrics were characterized by UV spectrophotometry and thermogravimetric analysis. The level of octyl methoxycinnamate entrapped in the Tencel tissue was determined by high-performance liquid chromatography and was found to be much higher (0.0203%, w/w) for the textile functionalised with beta-CDMCT compared to the unmodified fabric (0.0025%, w/w). In addition, spectrophotometric assessment of UV transmission through the fabric samples using the Transpore test showed that the in vitro sun protection factor of the textile support was markedly enhanced (3.2-fold increase) by impregnation with octyl methoxycinnamate of the beta-CDMCT grafted textile. Hence, even after repeated washings, the beta-CD finished fabric exhibits higher sunscreen agent retention and photoprotective properties than the unmodified textile material.
本研究的目的是研究防晒剂甲氧基肉桂酸辛酯共价结合到布纤维的环糊精空腔中的情况。通过与一氯三嗪基-β-环糊精（β-CDMCT）反应，将纤维素织物天丝接枝β-环糊精分子。将整理后的和未处理的纺织品浸泡在含有2%（v/v）防晒剂的水-甲醇混合物中，随后进行多次洗涤循环。通过紫外分光光度法和热重分析对未改性和改性织物进行表征。用高效液相色谱法测定了天丝组织中 entrapped 的甲氧基肉桂酸辛酯的含量，发现与未改性织物（0.0025%，w/w）相比，用β-CDMCT功能化的纺织品含量要高得多（0.0203%，w/w）。此外，使用透气测试对织物样品的紫外线透过率进行分光光度评估表明，β-CDMCT接枝纺织品用甲氧基肉桂酸辛酯浸渍后，织物载体的体外防晒系数显著提高（增加了3.2倍）。因此，即使经过反复洗涤，β-CD整理的织物比未改性的纺织材料表现出更高的防晒剂保留率和光保护性能。
