Wu Zhao-Hui, Mabb Angela, Miyamoto Shigeki
Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.
Cell. 2005 Dec 16;123(6):980-2. doi: 10.1016/j.cell.2005.11.025.
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.
为应对基因毒性应激，PIDD蛋白在肿瘤抑制蛋白p53的下游促进细胞凋亡。在本期《细胞》杂志中，扬森斯等人（2005年）证明，在应对这种应激时，PIDD形成一种核复合物，增强NEMO的类泛素化修饰。这种修饰对于抗凋亡转录因子NF-κB的激活很重要。
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