安非他酮缓释片治疗的患者偏好与依从性评估：一项基于网络的调查

An assessment of patient preference and adherence to treatment with Wellbutrin SR: a web-based survey.

作者信息

Granger Arthur L, Fehnel Sheri E, Hogue Susan L, Bennett Lee, Edin Heather M

机构信息

RTI Health Solutions, 3040 Cornwallis Rd. Research Triangle Park, NC 27709, USA.

出版信息

J Affect Disord. 2006 Feb;90(2-3):217-21. doi: 10.1016/j.jad.2005.08.018. Epub 2005 Dec 15.

DOI:10.1016/j.jad.2005.08.018

PMID:16360216

Abstract

BACKGROUND

Research has shown that lack of treatment adherence is a serious problem, especially among patients with psychiatric disorders. The current study was conducted to assess adherence and patient preference among individuals taking Wellbutrin SR (bupropion) for depression, as well as their interest in a once-daily formulation of bupropion.

METHODS

A 20-item web-based survey was administered to 527 individuals (276 men and 251 women) recruited through an online panel. All participants were at least 18 years of age, diagnosed with major depressive disorder, and had been taking Wellbutrin SR for at least 6 weeks. Survey items addressed treatment regimen, adherence, satisfaction with Wellbutrin SR, and interest in a once-daily formulation of bupropion.

RESULTS

The majority of respondents reported taking Wellbutrin SR twice a day (67%). Only 15% of once-daily users were nonadherent compared to 37% of twice-daily users and 65% of thrice-daily users. The most common reason reported for missing a dose of Wellbutrin SR was simply forgetting to take it (49% of twice-daily users and 65% of thrice-daily users). Results indicated that 77% of twice-daily users and 94% of thrice-daily users were interested in a once-daily formula.

CONCLUSIONS

A reduction in dosing frequency is favored by Wellbutrin SR users and likely to improve their adherence to treatment. Because greater adherence has been shown to facilitate symptom relief, improvements in quality of life, and reductions in healthcare expenses, the results of this study support the value of the recently released once-daily formulation, Wellbutrin XL.

摘要

背景

研究表明，缺乏治疗依从性是一个严重问题，尤其是在患有精神疾病的患者中。本研究旨在评估服用安非他酮缓释片（安非他酮）治疗抑郁症患者的依从性、患者偏好，以及他们对安非他酮每日一次剂型的兴趣。

方法

通过在线小组招募了527名个体（276名男性和251名女性），对其进行了一项包含20个条目的网络调查。所有参与者年龄至少为18岁，被诊断为重度抑郁症，且服用安非他酮缓释片至少6周。调查项目涉及治疗方案、依从性、对安非他酮缓释片的满意度，以及对安非他酮每日一次剂型的兴趣。

结果

大多数受访者报告每天服用两次安非他酮缓释片（67%）。每日一次服用者中只有15%不依从，而每日两次服用者为37%，每日三次服用者为65%。报告的漏服安非他酮缓释片最常见原因是单纯忘记服用（每日两次服用者中的49%和每日三次服用者中的65%）。结果表明，77%的每日两次服用者和94%的每日三次服用者对每日一次剂型感兴趣。