分子成像：当今可用的技术
Molecular imaging: what can be used today.
作者信息
Jager P L, de Korte M A, Lub-de Hooge M N, van Waarde A, Koopmans K P, Perik P J, de Vries E G E
机构信息
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center, Groningen, The Netherlands.
出版信息
Cancer Imaging. 2005 Nov 23;5 Spec No A(Spec No A):S27-32. doi: 10.1102/1470-7330.2005.0023.
Biochemical cellular targets and more general metabolic processes in cancer cells can be visualised. Extensive data are available on molecular imaging in preclinical models. However, innovative tracers move slowly to the clinic. This review provides information on the currently available methods of metabolic imaging, especially using PET in humans. The uptake mechanisms of tracer methods and a brief discussion of the more 'molecular' targeted methods are presented. The main focus is on the different classes of tracers and their application in various types of cancer within each class of tracers, based on the current literature and our own experience. Studies with [18F]FDG (energy metabolism), radiolabelled amino acids (protein metabolism), [18F]FLT (DNA metabolism), [11C]choline (cell membrane metabolism) as general metabolic tracer methods and [18F]DOPA (biogenic amine metabolism) as a more specific tracer method are discussed. As an example, molecular imaging methods that target the HER2 receptor and somatostatin receptor are described.
癌细胞中的生化细胞靶点和更一般的代谢过程可以可视化。在临床前模型中，关于分子成像有大量数据。然而，创新型示踪剂进入临床的速度较慢。本综述提供了有关当前可用的代谢成像方法的信息，特别是在人体中使用正电子发射断层扫描（PET）的情况。介绍了示踪剂方法的摄取机制，并对更具“分子”靶向性的方法进行了简要讨论。主要基于当前文献和我们自己的经验，重点关注不同类别的示踪剂及其在各类示踪剂中的各种癌症类型中的应用。讨论了使用[18F]氟代脱氧葡萄糖（能量代谢）、放射性标记氨基酸（蛋白质代谢）、[18F]氟代胸苷（DNA代谢）、[11C]胆碱（细胞膜代谢）作为一般代谢示踪剂方法，以及[18F]多巴（生物胺代谢）作为更特异性示踪剂方法的研究。作为示例，描述了靶向人表皮生长因子受体2（HER2）和生长抑素受体的分子成像方法。
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