Vaughan Christopher W
Pain Management Research Institute, Northern Clinical School, The University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, 2065, Australia.
Trends Pharmacol Sci. 2006 Feb;27(2):69-71. doi: 10.1016/j.tips.2005.11.011. Epub 2005 Dec 20.
A variety of physical and psychological stressors induce analgesia by activating descending systems that project from the brain to the spinal cord. This stress-induced analgesia (SIA) is mediated by distinct opioid- and non-opioid-dependent mechanisms. New evidence suggests that non-opioid SIA is mediated by two independent endocannabinoids within the midbrain. Furthermore, novel agents that disrupt breakdown of these endocannabinoids enhance non-opioid SIA and pave the way for novel therapies.
多种身体和心理应激源通过激活从大脑投射到脊髓的下行系统来诱导镇痛。这种应激诱导的镇痛（SIA）由不同的阿片类和非阿片类依赖性机制介导。新证据表明，非阿片类SIA由中脑内两种独立的内源性大麻素介导。此外，破坏这些内源性大麻素分解的新型药物可增强非阿片类SIA，并为新型疗法铺平道路。
