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慢性炎症性风湿性疾病——辅助临床诊断

Chronic inflammatory rheumatismal diseases--paraclinical diagnosis.

作者信息

Chicu Mihaela, Sorodoc L, Costuleanu M, Bădescu Magda, Lionte Cătălina

机构信息

Pathophysiology Department, "Gr. T. Popa" University of Medicine and Pharmacy, Iasi.

出版信息

Rom J Intern Med. 2004;42(4):671-84.

Abstract

The rheumatismal diseases constitute a major problem of public health, the pathology of the locomotor system representing today the main cause of invalidity in the world. The inflammatory chronic rheumatisms affect the young population, and, between the onset of the disease and diagnosis (approximately one year), the patient does not accuse major clinical complaints. In this context, the present work proposes a presentation of the main paraclinic methods and techniques, which may direct the clinician in giving a correct and early diagnosis of the main chronic inflammatory rheumatismal disorders. The paraclinic methods and techniques for assessing the intensity and evolution of the chronic rheumatismal inflammatory processes may be classified as follows: genetic, biological, histological, and imagistic. The inflammatory reaction is a nonspecific long-term reaction of the body defense systems, as response to the continuous and recurrent aggression. It is characterized by the predominance of the lymphocytes and macrophages at the level of the focus infectious and an intense process of neoangiogenesis and fibroblastic proliferation accompanies it. The paraclinic methods and techniques for assessing the intensity and evolution of the chronic rheumatismal inflammatory processes may be classified as follows: genetic, biological, histological, and imagistic.

摘要

风湿性疾病构成了一个重大的公共卫生问题,运动系统病理学如今是全球致残的主要原因。炎性慢性风湿病影响年轻人群,并且在疾病发作与诊断之间(约一年),患者并无明显的临床症状。在此背景下,本研究提出介绍主要的辅助临床方法和技术,这些方法和技术可指导临床医生对主要的慢性炎性风湿性疾病做出正确且早期的诊断。评估慢性风湿性炎症过程强度和进展的辅助临床方法和技术可分类如下:遗传学、生物学、组织学和影像学。炎症反应是机体防御系统的一种非特异性长期反应,作为对持续和反复侵袭的应答。其特征是在感染灶处淋巴细胞和巨噬细胞占优势,并且伴随着新血管生成和成纤维细胞增殖的强烈过程。评估慢性风湿性炎症过程强度和进展的辅助临床方法和技术可分类如下:遗传学、生物学、组织学和影像学。

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