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符合川崎病诊断标准并并发弥散性血管内凝血的4a型假结核耶尔森菌感染

[Yersinia pseudotuberculosis type 4a infection meeting the diagnostic criteria for Kawasaki disease complicated by disseminated intravascular coagulation].

作者信息

Usui Daisuke, Ishii Yoshiki, Akaike Hiroto, Isumi Hiroshi, Komura Hayasi, Kawasaki Kouzou, Ouchi Kazunobu

机构信息

Department of Pediatrics, Kawasaki Medical School Hospital.

出版信息

Kansenshogaku Zasshi. 2005 Nov;79(11):895-9. doi: 10.11150/kansenshogakuzasshi1970.79.895.

DOI:10.11150/kansenshogakuzasshi1970.79.895
PMID:16366361
Abstract

We report a case of Yersinia pseudotuberculosis (Y. ptbc) infection complicated by disseminated intravascular coagulation (DIC) that presented as Kawasaki disease (KD). A 9-year-old girl had been well until two days before, when she developed a fever, exanthem, and abdominal pain. An erythematous macular rash was observed in the perineum, and she had a strawberry tongue. The patient was admitted to Kawasaki Medical School Hospital because the macular rash spread over her entire body, and edema of her hands and conjunctivitis subsequently developed. Echo cardiography showed dilation of the left coronary artery. Thrombocytopenia and an elevated total fibrin degeneration product level were noted on the third hospital day, and the prothronmbin and partial-thromboplastin times were prolonged. Her clinical presentation was typical of KD and DIC. A stool culture and a blood culture were negative. Serologic tests were positive for antibodies to Y. ptbc. The antibody titer against Y. ptbc-derived mitogen was not elevated after her recovery. Y. ptbc infection should be considered in an older child whose clinical findings fulfill the criteria for KD complicated by DIC.

摘要

我们报告一例假结核耶尔森菌(Y. ptbc)感染并发弥散性血管内凝血(DIC),表现为川崎病(KD)。一名9岁女孩此前一直健康,直到两天前出现发热、皮疹和腹痛。会阴部观察到红斑性斑疹,且有草莓舌。由于斑疹蔓延至全身,随后出现手部水肿和结膜炎,该患者被收入川崎医科大学医院。超声心动图显示左冠状动脉扩张。住院第三天发现血小板减少以及总纤维蛋白降解产物水平升高,凝血酶原时间和部分凝血活酶时间延长。其临床表现为典型的KD和DIC。粪便培养和血培养均为阴性。血清学检测Y. ptbc抗体呈阳性。康复后针对Y. ptbc衍生丝裂原的抗体滴度未升高。对于临床表现符合KD并发DIC标准的大龄儿童,应考虑Y. ptbc感染。

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引用本文的文献

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Kawasaki Disease: The Role of Immune Complexes Revisited.川崎病:免疫复合物作用的再探讨。
Front Immunol. 2019 Jun 12;10:1156. doi: 10.3389/fimmu.2019.01156. eCollection 2019.
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Kawasaki disease with DIC as a complication.川崎病并发弥散性血管内凝血。
Indian J Pediatr. 2007 Nov;74(11):1049. doi: 10.1007/s12098-007-0197-5.