基于生物相容性两性离子二嵌段共聚物的pH敏感囊泡。

pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.

作者信息

Du Jianzhong, Tang Yiqing, Lewis Andrew L, Armes Steven P

机构信息

Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield S3 7HF, United Kingdom.

出版信息

J Am Chem Soc. 2005 Dec 28;127(51):17982-3. doi: 10.1021/ja056514l.

DOI:10.1021/ja056514l

PMID:16366531

Abstract

Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.

摘要

通过生物相容性两性离子共聚物聚[2-(甲基丙烯酰氧基)乙基磷酰胆碱-嵌段-2-(二异丙基氨基)乙基甲基丙烯酸酯]（PMPC-b-PDPA）的自组装制备了具有高度生物相容性的pH敏感双嵌段共聚物囊泡。通过将溶液pH从pH 2调节至6以上，疏水性PDPA链形成囊泡壁，囊泡自发形成。使用透射电子显微镜（TEM）、动态激光光散射（DLS）和紫外可见吸收分光光度法对这些囊泡进行表征。通过用HAuCl4处理囊泡，然后用NaBH4处理，还获得了金纳米颗粒修饰的囊泡。