Marsch Lisa A, Stephens Mary Ann Chutuape, Mudric Timothy, Strain Eric C, Bigelow George E, Johnson Rolley E
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Exp Clin Psychopharmacol. 2005 Nov;13(4):293-302. doi: 10.1037/1064-1297.13.4.293.
This study examined (1) predictors of treatment outcome for opioid-dependent participants in a single-site controlled trial comparing methadone, buprenorphine, and LAAM treatments and (2) the extent to which various subpopulations of patients may have more successful outcomes with each medication. The relationships between patient demographics, drug use history, and psychological status and outcome measures of treatment retention, opiate use, and cocaine use were assessed. We believe this study to be the first to demonstrate that predictors of treatment success appear to be largely similar in LAAM, buprenorphine, and methadone treatment for opioid dependence. We did not find any factors that would strongly guide selection of one medication over others.
（1）在一项比较美沙酮、丁丙诺啡和长效阿片类激动剂（LAAM）治疗的单中心对照试验中，阿片类药物依赖参与者治疗结果的预测因素；（2）不同亚组患者使用每种药物可能取得更成功治疗结果的程度。评估了患者人口统计学特征、药物使用史、心理状态与治疗保留率、阿片类药物使用及可卡因使用等治疗结果指标之间的关系。我们认为本研究首次证明，对于阿片类药物依赖，LAAM、丁丙诺啡和美沙酮治疗中治疗成功的预测因素似乎大体相似。我们未发现任何能有力指导选择一种药物而非其他药物的因素。
