NG2：神经胶质瘢痕的一种成分，可抑制轴突生长。
NG2: a component of the glial scar that inhibits axon growth.
作者信息
Tan Andrew M, Zhang Weibing, Levine Joel M
机构信息
Department of Neurobiology and Behavior, State University of New York, Stony Brook, NY 11794, USA.
出版信息
J Anat. 2005 Dec;207(6):717-25. doi: 10.1111/j.1469-7580.2005.00452.x.
Abstract
NG2 is a high-molecular-weight chondroitin sulphate proteoglycan found on the surfaces of oligodendrocyte precursor cells (OPCs). Here we review the history and biology of OPCs with an emphasis on their functions after experimentally induced CNS injury. Injury to brain or spinal cord results in the rapid accumulation of NG2-expressing OPCs in the glial scar that forms at the injury site. The glial scar is considered a biochemical and physical barrier to successful axon regeneration and the functional properties of NG2 suggest that it, along with other macromolecules, participates in the creation of this growth-inhibitory environment. NG2 is an important target for therapies designed to promote successful axon regrowth.
摘要
NG2是一种高分子量硫酸软骨素蛋白聚糖，存在于少突胶质前体细胞（OPC）表面。在此，我们回顾OPC的历史和生物学特性，重点关注其在实验性诱导的中枢神经系统损伤后的功能。脑或脊髓损伤会导致表达NG2的OPC在损伤部位形成的胶质瘢痕中迅速积聚。胶质瘢痕被认为是轴突成功再生的生化和物理屏障，NG2的功能特性表明它与其他大分子一起参与了这种生长抑制环境的形成。NG2是旨在促进轴突成功再生的治疗的重要靶点。
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