Nishiyama Akiko
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269-3156, USA.
Neuroscientist. 2007 Feb;13(1):62-76. doi: 10.1177/1073858406295586.
NG2 cells, or polydendrocytes, are defined as glial cells that express the NG2 proteoglycan and represent a fourth major glial cell population in the mammalian central nervous system. They are morphologically, antigenically, and functionally distinct from mature astrocytes, oligodendrocytes, and microglia. Although they are most often equated with oligodendrocyte progenitor cells, they exhibit some properties that are not commonly associated with those of progenitor cells that generate myelinating cells. This review discusses recent observations and unanswered issues related to their lineage and their role in remyelination, neural signaling, and axonal growth.
NG2细胞，即多突胶质细胞，被定义为表达NG2蛋白聚糖的神经胶质细胞，是哺乳动物中枢神经系统中的第四种主要神经胶质细胞群。它们在形态、抗原性和功能上与成熟的星形胶质细胞、少突胶质细胞和小胶质细胞不同。尽管它们常被等同于少突胶质前体细胞，但它们表现出一些与产生髓鞘细胞的前体细胞通常不相关的特性。这篇综述讨论了与它们的谱系以及它们在髓鞘再生、神经信号传导和轴突生长中的作用相关的最新观察结果和未解决的问题。
