Perrotti Vittoria, Rubini Corrado, Fioroni Massimiliano, Piattelli Adriano
Dental School, University of Chieti-Pescara, Italy.
J Clin Periodontol. 2006 Jan;33(1):76-8. doi: 10.1111/j.1600-051X.2005.00837.x.
Soft tissue myxoma of the oral cavity is rare. Only three cases of myxoma of gingiva have been reported in the literature. We present a case of soft tissue myxoma arising from the left maxillary adherent gingiva in a 42-year-old male [correction of female] patient.
Histological examination showed spindle-shaped cells in a myxoid stroma. Immunohistochemical stains with S-100 protein were negative, while those with vimentin were positive.
Clinical examination revealed a soft tissue mass, with tense elastic consistency on palpation. The overlying mucosa was normal and healthy. A clinical diagnosis of fibroma was given. Histological examination showed spindle-shaped and stellate cells, arranged in a myxoid fibrous stroma, with collagen fibres distributed uniformly. Scattered islands or strands of inactive odontogenic epithelium were present. On the basis of the histological and immunohistochemical findings, the final diagnosis was soft tissue myxoma.
Further studies are necessary to clarify the origin and histogenesis of this lesion.
口腔软组织黏液瘤较为罕见。文献中仅报道过3例牙龈黏液瘤。我们报告1例42岁男性[原译有误,应为男性]患者,其左上颌附着龈出现软组织黏液瘤。
组织学检查显示黏液样基质中有梭形细胞。S-100蛋白免疫组化染色阴性,波形蛋白免疫组化染色阳性。
临床检查发现一个软组织肿块,触诊时有紧张的弹性质地。覆盖其上的黏膜正常且健康。临床诊断为纤维瘤。组织学检查显示梭形和星状细胞,排列在黏液样纤维基质中,胶原纤维分布均匀。可见散在的岛状或条索状无活性牙源性上皮。根据组织学和免疫组化结果,最终诊断为软组织黏液瘤。
有必要进一步研究以阐明该病变的起源和组织发生。