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[钙过敏:一种罕见的系统性血管炎鉴别诊断]

[Calciphylaxis: a rare differential diagnosis of systemic vasculitis].

作者信息

Khellaf M, Wechsler J, Roucayrol A-M, Roujeau J-C, Godeau B

机构信息

Service de Médecine Interne, CHU Henri-Mondor, 51, avenue de Lattre-de-Tassigny, 94010 Créteil, France.

出版信息

Rev Med Interne. 2006 Mar;27(3):240-3. doi: 10.1016/j.revmed.2005.10.019. Epub 2005 Dec 9.

Abstract

INTRODUCTION

Calciphylaxis is a rare phenomenon of medium- and small-vessel calcifications leading to cutaneous necrosis mimicking vasculitis.

CASE REPORT

A 75 year-old-woman with chronic renal insufficiency was admitted for extensive cutaneous necrosis of the limb. Diagnosis of vasculitis was made, but inspite of corticosteroid therapy, the condition of the patient was worsening. After cutaneous biopsy, the diagnosis of calciphylaxis was established.

CONCLUSION

Calciphylaxis must be suspected in cases of cutaneous necrosis occurring in a patient with chronic renal failure. Treatment requires rapid normalization of phosphocalcic balance. It is a condition with high mortality.

摘要

引言

钙化防御是一种罕见的中小血管钙化现象,可导致类似血管炎的皮肤坏死。

病例报告

一名75岁慢性肾功能不全女性因肢体广泛皮肤坏死入院。诊断为血管炎,但尽管进行了皮质类固醇治疗,患者病情仍在恶化。皮肤活检后,确诊为钙化防御。

结论

慢性肾衰竭患者出现皮肤坏死时,必须怀疑钙化防御。治疗需要迅速使钙磷平衡正常化。这是一种死亡率很高的疾病。

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