8-氨基腺苷5'-（氨基烷基磷酸酯）的合成，即氨酰腺苷酸类似物。
Synthesis of 8-aminoadenosine 5'-(aminoalkyl phosphates), analogues of aminoacyl adenylates.
作者信息
Yousefi-Salakdeh Esmail, Murtola Merita, Zetterberg Anders, Yeheskiely Esther, Strömberg Roger
机构信息
Division of Organic and Bioorganic Chemistry, MBB, Scheele Laboratory, Karolinska Institutet, S-17177 Stockholm, Sweden.
出版信息
Bioorg Med Chem. 2006 Apr 15;14(8):2653-9. doi: 10.1016/j.bmc.2005.11.049. Epub 2005 Dec 20.
PMID:16368242
Abstract
A short and efficient route for the synthesis of aminoalkyl 8-aminoadenylates, potential aminoacyl-tRNA synthetase inhibitors, is presented. Aminoalkyl 8-aminoadenylates were synthesized using a 5'-H-phosphonate strategy involving minimal protecting group manipulations and a single final deprotection step.
摘要
本文介绍了一种合成氨基烷基8-氨基腺苷酸酯（潜在的氨酰-tRNA合成酶抑制剂）的简短而高效的路线。氨基烷基8-氨基腺苷酸酯是采用5'-H-膦酸酯策略合成的，该策略涉及最少的保护基操作和单一的最终脱保护步骤。
Zotero 插件