Papapetropoulos Spiridon, McCorquodale Donald S, Gonzalez Jocely, Jean-Gilles Lucie, Mash Deborah C
Department of Neurology, Miller School of Medicine, University of Miami, 1501 NW 9th Avenue (NPF), Room 4004, Miami, FL 33136, USA.
Parkinsonism Relat Disord. 2006 May;12(4):253-6. doi: 10.1016/j.parkreldis.2005.10.005. Epub 2005 Dec 20.
Visual hallucinations (VH) are among the most common non-motor complications of Parkinson's disease (PD). A few studies on their etiopathogenesis have suggested involvement of cortical and amygdalar areas. In order to investigate the possible association between extranigral Lewy Body (LB) distribution across cortical and amygdalar regions and the presence of VH in PD brain donors, we conducted a clinico-pathological comparison of 10 PD patients with VH vs 10 closely matched PD patients without VH. The LB burden was significantly higher across the amygdala and the frontal, temporal and parietal cortical areas in patients with VH. Although our results suggest significant extranigral involvement, the precise etiopathologic mechanisms responsible for the development of VH need further clarification.
视幻觉（VH）是帕金森病（PD）最常见的非运动并发症之一。一些关于其病因发病机制的研究表明，皮质和杏仁核区域参与其中。为了研究跨皮质和杏仁核区域的黑质外路易体（LB）分布与PD脑供体中VH存在之间的可能关联，我们对10例有VH的PD患者和10例匹配良好的无VH的PD患者进行了临床病理比较。有VH的患者，杏仁核以及额叶、颞叶和顶叶皮质区域的LB负担明显更高。虽然我们的结果表明存在显著的黑质外受累，但导致VH发生的确切病因病理机制仍需进一步阐明。
