Chen Wanjun
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Heath, 30, Bethesda, MD 20892, USA.
Front Biosci. 2006 May 1;11:1360-70. doi: 10.2741/1889.
Dendritic cells (DCs) are professional antigen presenting cells (APCs). (CD4+)CD25+ T regulatory cells (T regs) are recognized as professional regulatory cells. DCs not only initiate T cell immunity by uptake, processing and presentation of specific antigens, but also induce immune tolerance by deletion of T cells and/or induction of regulatory T cells. (CD4+)CD25+ T regs maintain immune tolerance by suppressing the function of CD4+ and CD8+ T cells, B cells, macrophages, DCs and NK cells. It would be inconceivable that the delicate balance between immunity and tolerance could be kept impeccable without the crosstalk between DCs and (CD4+)CD25+ T regs. This review focuses on the recent development in our understanding of DCs and (CD4+)CD25+ T regs in immune tolerance, with transforming growth factor-beta (TGF-beta) serving as a potential link between these two professionals.
树突状细胞（DCs）是专职抗原呈递细胞（APCs）。（CD4 +）CD25 + T调节细胞（Tregs）被认为是专职调节细胞。DCs不仅通过摄取、加工和呈递特定抗原来启动T细胞免疫，还通过T细胞的缺失和/或调节性T细胞的诱导来诱导免疫耐受。（CD4 +）CD25 + Tregs通过抑制CD4 +和CD8 + T细胞、B细胞、巨噬细胞、DCs和NK细胞的功能来维持免疫耐受。如果没有DCs和（CD4 +）CD25 + Tregs之间的相互作用，免疫和耐受之间的微妙平衡能够保持完美无缺是不可想象的。本综述重点关注我们对DCs和（CD4 +）CD25 + Tregs在免疫耐受方面理解的最新进展，转化生长因子-β（TGF-β）作为这两种专职细胞之间的潜在联系。
