钙调蛋白对电压门控性钙离子通道的调节作用。
Regulation of voltage-gated Ca2+ channels by calmodulin.
作者信息
Halling D Brent, Aracena-Parks Paula, Hamilton Susan L
机构信息
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Sci STKE. 2005 Dec 20;2005(315):re15. doi: 10.1126/stke.3152005re15.
Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 and Cav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels.
钙调蛋白是一种高度通用且广泛表达的钙离子传感器，可调节许多酶和离子通道的功能。电压门控钙离子通道Cav1.2和Cav2.1的钙离子依赖性失活和钙离子依赖性易化均通过与钙离子结合的钙调蛋白相互作用来调节。本文综述了钙调蛋白对Cav1.2和Cav2.1的功能调节，并讨论了钙离子与单个钙调蛋白分子结合如何调节电压门控钙离子通道的相反功能。
Zotero 插件