Bartholomew J C, Salmon A G, Gamper H B, Calvin M
Cancer Res. 1975 Mar;35(3):851-6.
The effect of benzo (a) pyrene on the growth in culture of 5 mouse epithelial cell strains was examined. These epithelial cells are highly sensitive to the cytotoxic action of benzo (a)-pyrene. In addition, the activity of the benzol (a) pyrene-metabolizing system, aryl hydrocarbon hydroxylase, is low but highly iducible by the carcinogen. As the sensitivity of a cell strain to the cytotoxic action of benjo (a) pyrene decreased, the inudcibility of the hydroxylase also decreased,. However, a strong correlation could not be found between cytotoxicity and the level of uninduced or induced hydroxylase when the values from different cell strains were compared. These experiments suggest that thehydroxylase is important in determining the sensitivity of epithelial cells to the cytotoxic action of benzo (a) pyrene, but other factors may also modulate this sensitivity.
研究了苯并（a）芘对5种小鼠上皮细胞系培养生长的影响。这些上皮细胞对苯并（a）芘的细胞毒作用高度敏感。此外，苯并（a）芘代谢系统芳烃羟化酶的活性较低，但可被致癌物高度诱导。随着细胞系对苯并（a）芘细胞毒作用的敏感性降低，羟化酶的诱导性也降低。然而，当比较不同细胞系的值时，在细胞毒性与未诱导或诱导的羟化酶水平之间未发现强相关性。这些实验表明，羟化酶在确定上皮细胞对苯并（a）芘细胞毒作用的敏感性方面很重要，但其他因素也可能调节这种敏感性。
