Oyawoye Oluseye A, Chander Bina, Hunter Jocelyn, Gadir Ahmed Abdel
Department of Obstetrics and Gynaecology, Royal Free Campus, Royal Free and University College Medical School, London, UK.
MedGenMed. 2005 Aug 16;7(3):60.
This study was designed to assess the efficacy of early aspiration of small follicles (EASF) in preventing moderate and severe ovarian hyperstimulation syndrome (OHSS) in women with polycystic ovaries who experienced excessive ovarian response during the early part of assisted reproductive treatment cycles (ART).
EASF was undertaken transvaginally during 15 in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles in 14 women with polycystic ovaries who produced more than 20 small follicles during the early part of the cycle. A minimum of 10 small follicles.
None of the patients developed moderate or severe OHSS. There were 9 intrauterine pregnancies (60 %) and 1 ectopic pregnancy.
EASF 4 to 7 days after starting gonadotropin injections prevented moderate and severe OHSS in susceptible patients with polycystic ovaries and resulted in a high pregnancy rate. Larger studies are needed to verify these promising results.
本研究旨在评估早期抽吸小卵泡（EASF）对预防多囊卵巢女性在辅助生殖治疗周期（ART）早期出现过度卵巢反应时发生中度和重度卵巢过度刺激综合征（OHSS）的疗效。
在14例多囊卵巢女性的15个体外受精（IVF）或卵胞浆内单精子注射（ICSI）周期中，于周期早期经阴道进行EASF，这些女性在周期早期产生了超过20个小卵泡，至少10个小卵泡。
无患者发生中度或重度OHSS。有9例宫内妊娠（60%）和1例异位妊娠。
在注射促性腺激素4至7天后进行EASF可预防多囊卵巢易感患者发生中度和重度OHSS，并导致高妊娠率。需要更大规模的研究来验证这些有前景的结果。
