ffrench-Constant Richard, Daborn Philip, Feyereisen Rene
Department of Biology, University of Bath, Bath, UK.
Bioessays. 2006 Jan;28(1):6-8. doi: 10.1002/bies.20354.
Transposons are well-known architects of genetic change but their role in insecticide resistance has, until recently, only been speculated upon. Transposon insertion, or transposon-mediated transposition, could alter either metabolic enzymes capable of degrading pesticides or could change the functionality of insecticide targets. The recent work of Aminetzach and coworkers suggests an exciting alternative, that transposon insertion can cause resistance by altering gene product function. This hypothesis is discussed in the light of other examples in which transposons have been implicated in insecticide resistance.
转座子是众所周知的基因变化缔造者，但直到最近，它们在抗杀虫剂方面的作用一直只是推测。转座子插入或转座子介导的转位，可能会改变能够降解农药的代谢酶，或者改变杀虫剂靶标的功能。阿明采赫及其同事最近的研究提出了另一种令人兴奋的可能性，即转座子插入可通过改变基因产物功能导致抗性。根据转座子与抗杀虫剂有关的其他例子对这一假说进行了讨论。
