McClellan W M, Flanders W D, Gutman R A
Emory School of Medicine, Atlanta, Georgia.
Ann Intern Med. 1992 Aug 15;117(4):332-6. doi: 10.7326/0003-4819-117-4-332.
To examine the variation in the risk for mortality among patients treated at renal dialysis facilities within a defined geographic area.
All free-standing and hospital-based dialysis facilities in a single southeastern state reported to the registry.
Cohort of dialysis patients followed for 1 year by an end-stage renal disease registry.
Patients (n = 3612) aged 20 years and older receiving treatment at the dialysis facilities reporting to the registry during 1987.
Demographic, comorbid, and severity of illness indicators were abstracted from patient records. Facility-specific risk estimates were derived from a Cox proportional hazards model.
Facility-specific mortality rates ranged between 2.0 and 10.5 deaths per 10,000 patient days. Mortality rates were higher among older persons; whites; those with a history of diabetic nephropathy, angina, or congestive heart failure; and patients with either nutritional or functional status impairment. Facility-specific prevalence of each mortality risk factor varied widely. The unadjusted risk for death in a facility at the 75th percentile of risk was 1.3 times that of a facility at the median, whereas at the 25th percentile, it was 0.68 times as likely--a twofold range of risk. Controlling for differences in the prevalence of patient characteristics did not change the interquartile range in risks, and a facility's adjusted risk estimate showed a strong correlation with its unadjusted estimate (R2, 0.566; P less than 0.0001).
Patient attributes associated with increased risk for mortality vary widely among dialysis facilities. Adjustment for these differences did not, however, substantially change either the degree of variation in mortality risks or the relative ranking of a facility's mortality.
研究特定地理区域内接受肾透析治疗的患者的死亡风险差异。
向登记处报告的美国东南部一个州的所有独立及医院附属透析机构。
由终末期肾病登记处对透析患者队列进行为期1年的随访。
1987年期间在向登记处报告的透析机构接受治疗的20岁及以上患者(n = 3612)。
从患者记录中提取人口统计学、合并症和疾病严重程度指标。特定机构的风险估计值来自Cox比例风险模型。
特定机构的死亡率在每10000患者日2.0至10.5例死亡之间。老年人、白人、有糖尿病肾病、心绞痛或充血性心力衰竭病史的患者以及营养或功能状态受损的患者死亡率较高。各死亡风险因素在不同机构中的患病率差异很大。风险处于第75百分位的机构的未调整死亡风险是处于中位数的机构的1.3倍,而在第25百分位时,其死亡风险是中位数机构的0.68倍——风险范围达两倍。控制患者特征患病率的差异并未改变风险的四分位间距,且机构的调整后风险估计值与其未调整估计值显示出很强的相关性(R2,0.566;P < 0.0001)。
与死亡风险增加相关的患者属性在不同透析机构中差异很大。然而,对这些差异进行调整并未显著改变死亡风险的变化程度或机构死亡率的相对排名。