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Similar inhibition of mitochondrial respiration by 1-methyl-4-phenyl-pyridinium (MPP+) and by a unique N-methylated beta-carboline analogue, 2,9-dimethyl-norharman (2,9Me2NH).

作者信息

Fields J Z, Albores R, Neafsey E J, Collins M A

机构信息

Department of Pharmacology, Loyola University, Stritch School of Medicine, Maywood, Illinois 60153.

出版信息

Ann N Y Acad Sci. 1992 May 11;648:272-4. doi: 10.1111/j.1749-6632.1992.tb24554.x.

DOI:10.1111/j.1749-6632.1992.tb24554.x
PMID:1637055
Abstract
摘要

相似文献

1
Similar inhibition of mitochondrial respiration by 1-methyl-4-phenyl-pyridinium (MPP+) and by a unique N-methylated beta-carboline analogue, 2,9-dimethyl-norharman (2,9Me2NH).1-甲基-4-苯基吡啶鎓（MPP+）和一种独特的N-甲基化β-咔啉类似物2,9-二甲基去甲哈尔满（2,9Me2NH）对线粒体呼吸具有类似的抑制作用。
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2
Mitochondrial respiratory inhibition by N-methylated beta-carboline derivatives structurally resembling N-methyl-4-phenylpyridine.结构类似于N-甲基-4-苯基吡啶的N-甲基化β-咔啉衍生物对线粒体呼吸的抑制作用
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Is complex II involved in the inhibition of mitochondrial respiration by N-methyl-4-phenylpyridinium cation (MMP+) and N-methyl-beta-carbolines?复合物II是否参与了N-甲基-4-苯基吡啶阳离子（MMP+）和N-甲基-β-咔啉对线粒体呼吸的抑制作用？
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4'-alkylated analogs of 1-methyl-4-phenylpyridinium ion are potent inhibitors of mitochondrial respiration.
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6
Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria.1-甲基-4-苯基吡啶鎓（MPP+）类似物对线粒体呼吸和NADH氧化酶的抑制作用及其在线粒体中的能量依赖性积累的结构依赖性
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Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration.与1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）结构相关的异喹啉衍生物对线粒体呼吸的影响。
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Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP.4-苯基吡啶类似物和1-甲基-4-苯基吡啶阳离子（MPP+，MPTP的神经毒性代谢产物）对线粒体呼吸的抑制作用。
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1-Methyl-4-phenylpyridinium (MPP+) inhibits mitochondrial oxygen consumption mediated by succinate as well as malate in rat pheochromocytoma PC12 cells.1-甲基-4-苯基吡啶离子（MPP+）抑制大鼠嗜铬细胞瘤PC12细胞中由琥珀酸和苹果酸介导的线粒体氧消耗。
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Enhancement by tetraphenylboron of the interaction of the 1-methyl-4-phenylpyridinium ion (MPP+) with mitochondria.四苯基硼增强1-甲基-4-苯基吡啶离子（MPP+）与线粒体的相互作用。
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引用本文的文献

1
Norharman-induced motoric impairment in mice: neurodegeneration and glial activation in substantia nigra.去甲哈尔满诱导的小鼠运动功能障碍：黑质中的神经退行性变和胶质细胞激活。
J Neural Transm (Vienna). 2006 Mar;113(3):313-29. doi: 10.1007/s00702-005-0334-0. Epub 2005 Aug 3.
2
Elevated levels of harman and norharman in cerebrospinal fluid of parkinsonian patients.帕金森病患者脑脊液中哈尔满和去甲哈尔满水平升高。
J Neural Transm (Vienna). 1996;103(12):1435-40. doi: 10.1007/BF01271257.