维生素D3对25-羟基胆钙化醇代谢的反馈调节
Feedback regulation of 25-hydroxycholecalciferol metabolism by vitamin D3.
作者信息
Evans I M, Colston K W, Galante L, MacIntyre I
出版信息
Clin Sci Mol Med. 1975 Mar;48(3):227-30. doi: 10.1042/cs0480227.
PMID:163720
Abstract
- In vitamin D-deficient chicks both vitamin D3 and 1alpha-hydroxycholecalciferol markedly decrease renal 1-hydroxylase activity and induce 24-hydroxylase activity. 2. Actinomycin D abolishes both effects. 3. These results are consistent with feedback regulation of vitamin D3 metabolism by a direct nuclear action of the vitamin or its metabolites on the kidney cells.
摘要
- 在维生素D缺乏的雏鸡中，维生素D3和1α-羟胆钙化醇均显著降低肾脏1-羟化酶活性并诱导24-羟化酶活性。2. 放线菌素D可消除这两种效应。3. 这些结果与维生素D3代谢的反馈调节一致，即维生素或其代谢产物对肾细胞的直接核作用。
相似文献
1
Feedback regulation of 25-hydroxycholecalciferol metabolism by vitamin D3.维生素D3对25-羟基胆钙化醇代谢的反馈调节
Clin Sci Mol Med. 1975 Mar;48(3):227-30. doi: 10.1042/cs0480227.
2
Feedback regulation of vitamin D metabolism by 1,25-dihydroxycholecalciferol.1,25-二羟胆钙化醇对维生素D代谢的反馈调节
Biochem J. 1977 Apr 15;164(1):83-9. doi: 10.1042/bj1640083.
3
Regulation and its refractoriness of 25-hydroxyvitamin D3 metabolism in vitamin D deficiency.维生素D缺乏时25-羟基维生素D3代谢的调节及其难治性
J Nutr Sci Vitaminol (Tokyo). 1981;27(5):429-37. doi: 10.3177/jnsv.27.429.
4
The regulation of vitamin D metabolism.维生素D代谢的调节
Adv Exp Med Biol. 1977;81:251-61. doi: 10.1007/978-1-4613-4217-5_25.
5
6
Direct involvement of vitamin D in the regulation of 25-hydroxycholecalciferol metabolism.维生素D直接参与25-羟胆钙化醇代谢的调节。
FEBS Lett. 1974 Aug 1;43(3):353-6. doi: 10.1016/0014-5793(74)80678-2.
7
Metabolism of 25-hydroxyvitamin D3 in kidney homogenates of chicks supplemented with vitamin D3.补充维生素D3的雏鸡肾脏匀浆中25-羟基维生素D3的代谢
Biochem Biophys Res Commun. 1978 Nov 29;85(2):601-7. doi: 10.1016/0006-291x(78)91205-6.
8
The 24-hydroxylation of 1,25-dihydroxyvitamin D3.1,25-二羟基维生素D3的24-羟化作用
J Biol Chem. 1977 Feb 25;252(4):1421-4.
9
Influence of estrogen on renal vitamin D hydroxylases and serum 1alpha,25-(OH)2D3 in chicks.雌激素对雏鸡肾脏维生素D羟化酶及血清1α,25-(OH)₂D₃的影响
Am J Physiol. 1978 Sep;235(3):E338-43. doi: 10.1152/ajpendo.1978.235.3.E338.
10
Regulation of 25-hydroxyvitamin D3-1-hydroxylase in vivo.体内25-羟基维生素D3-1-羟化酶的调节
J Biol Chem. 1974 Dec 10;249(23):7584-92.
Zotero 插件