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平行板流动腔中早期生物膜形成及抗菌剂对正畸粘结材料的影响

Early biofilm formation and the effects of antimicrobial agents on orthodontic bonding materials in a parallel plate flow chamber.

作者信息

Chin Mervyn Y H, Busscher Henk J, Evans Robert, Noar Joseph, Pratten Jonathan

机构信息

Department Orthodontics, University Medical Center Groningen, The Netherlands.

出版信息

Eur J Orthod. 2006 Feb;28(1):1-7. doi: 10.1093/ejo/cji094. Epub 2005 Dec 22.

Abstract

Decalcification is a commonly recognized complication of orthodontic treatment with fixed appliances. A technology, based on a parallel plate flow chamber, was developed to investigate early biofilm formation of a strain of Streptococcus sanguis on the surface of four orthodontic bonding materials: glass ionomer cement (Ketac Cem), resin-modified glass ionomer cement (Fuji Ortho LC), chemically-cured composite resin (Concise) and light-cured composite resin (Transbond XT). S. sanguis was used as it is one of the primary colonizers of dental hard surfaces. Artificial saliva was supplied as a source of nutrients for the biofilms. The effects of two commercially available mouthrinses (i.e. a fluoride containing rinse and chlorhexidine) were evaluated. Initial colonization of the bacterium was assessed after 6 hours of growth by the percentage surface coverage (PSC) of the biofilm on the disc surfaces. There were statistically significant differences in bacterial accumulation between different bonding materials (P < 0.05), Concise being the least colonized and Transbond XT being the most colonized by S. sanguis biofilms. All materials pre-treated with 0.05 per cent sodium fluoride mouthrinse showed more than 50 per cent reduction in biofilm formation. The 0.2 per cent chlorhexidine gluconate mouthrinse caused significant reduction of biofilm formation on all materials except Ketac Cem. This in vitro study showed that the use of a chemically-cured composite resin (Concise) reduced early S. sanguis biofilm formation. Also, fluoride had a greater effect in reducing the PSC by S. sanguis biofilms than chlorhexidine. Rinsing with 0.05 per cent sodium fluoride prior to placement of orthodontic appliances is effective in reducing early biofilm formation.

摘要

脱钙是固定矫治器正畸治疗中一种常见的并发症。基于平行板流动腔开发了一种技术,用于研究血链球菌菌株在四种正畸粘结材料表面的早期生物膜形成情况,这四种材料分别是玻璃离子水门汀(Ketac Cem)、树脂改性玻璃离子水门汀(Fuji Ortho LC)、化学固化复合树脂(Concise)和光固化复合树脂(Transbond XT)。选用血链球菌是因为它是牙齿硬表面的主要定植菌之一。提供人工唾液作为生物膜的营养来源。评估了两种市售漱口水(即含氟漱口水和氯己定)的效果。在生长6小时后,通过圆盘表面生物膜的表面覆盖率(PSC)评估细菌的初始定植情况。不同粘结材料之间的细菌积累存在统计学显著差异(P < 0.05),Concise被血链球菌生物膜定植的程度最低,而Transbond XT被定植的程度最高。用0.05%氟化钠漱口水预处理的所有材料生物膜形成减少了50%以上。0.2%葡萄糖酸氯己定漱口水使除Ketac Cem外的所有材料上的生物膜形成显著减少。这项体外研究表明,使用化学固化复合树脂(Concise)可减少血链球菌早期生物膜形成。此外,氟化物在降低血链球菌生物膜的PSC方面比氯己定效果更好。在放置正畸矫治器之前用0.05%氟化钠漱口可有效减少早期生物膜形成。

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