Al-Qawasmi Riyad A, Hartsfield James K, Everett Eric T, Weaver Marjorie R, Foroud Tatiana M, Faust Deidra M, Roberts W Eugene
Department of Oral Facial Development, Indiana University School of Dentistry, IN 46202-5186, USA.
Eur J Orthod. 2006 Feb;28(1):13-9. doi: 10.1093/ejo/cji090. Epub 2005 Dec 22.
Root resorption (RR) is an unwanted sequela of orthodontic treatment. Despite rigorous investigation, no single factor or group of factors that directly causes RR has been identified. The purpose of this study was to examine the effect of the genotype on susceptibility or resistance to develop RR secondary to orthodontic force. Nine-week-old male mice from eight inbred strains were used and randomly distributed into control (C) or treatment (T) groups as follows: A/J (C = 9,T = 9), C57BL/6J (C = 7,T = 8), C3H/HeJ (C = 8,T = 6), BALB/cJ (C = 8,T = 6), 129P3/J (C = 6,T = 8), DBA/2J (C = 8,T = 9), SJL/J (C = 8,T = 10), and AKR/J (C = 9,T = 8). Each of the treated mice received an orthodontic appliance to tip the maxillary left first molar mesially for 9 days. Histological sections of the tooth were used to determine RR and tartrate resistant acid phosphatase (TRAP) activity. The Wilcoxon ranked-sum non-parametric test was used to evaluate differences between the groups. The results showed that the DBA/2J, BALB/cJ, and 129P3/J inbred mouse strains are highly susceptible to RR, whereas A/J, C57BL/6J and SJL/J mice are much more resistant. The variation in the severity of RR associated with orthodontic force among different inbred strains of mice when age, gender, food, housing, and orthodontic force magnitude/duration are controlled support the hypothesis that susceptibility or resistance to RR associated with orthodontic force is a genetically influenced trait.
牙根吸收（RR）是正畸治疗中一种不良的后遗症。尽管进行了严格的研究，但尚未确定直接导致RR的单一因素或因素组。本研究的目的是探讨基因型对正畸力继发RR的易感性或抗性的影响。使用来自八个近交系的9周龄雄性小鼠，并随机分为对照组（C）或治疗组（T），如下：A/J（C = 9，T = 9）、C57BL/6J（C = 7，T = 8）、C3H/HeJ（C = 8，T = 6）、BALB/cJ（C = 8，T = 6）、129P3/J（C = 6，T = 8）、DBA/2J（C = 8，T = 9）、SJL/J（C = 8，T = 10）和AKR/J（C = 9，T = 8）。每只接受治疗的小鼠都佩戴正畸矫治器，使上颌左侧第一磨牙向近中倾斜9天。牙齿的组织学切片用于确定RR和抗酒石酸酸性磷酸酶（TRAP）活性。采用Wilcoxon秩和非参数检验评估组间差异。结果表明，DBA/2J、BALB/cJ和129P3/J近交系小鼠对RR高度易感，而A/J、C57BL/6J和SJL/J小鼠则更具抗性。当年龄、性别、食物、饲养环境和正畸力大小/持续时间得到控制时，不同近交系小鼠正畸力相关RR严重程度的差异支持了以下假设：正畸力相关RR的易感性或抗性是一种受遗传影响的性状。
